Endocrine Abstracts

Treatment of transgender patients has gained increasing importance in outpatient endocrinological care due to a steadily rising influx of patients in recent years. Many gaps in knowledge regarding hormonal therapy have been filled in recent years thanks to a growing body of literature based on larger cohort studies. Nowadays therapy can be regarded as safe and effective. While puberty arrest and peripubertal hormone treatment in transgender youth has gained growing acceptance ...

Objective: Nonalcoholic fatty liver disease (NAFLD) is a hallmark of the metabolic syndrome and has been shown to be an independent predictor of cardiovascular mortality. Although glucocorticoids and growth hormone are known to be implicated in its pathophysiology, it has only rarely been investigated in the context of patients with pituitary insufficiency or former cortisol excess.Design: Case-control study, including patients with biochemically control...

Neuroimaging techniques have improved over the last years; hence an “empty sella” is more often incidentally diagnosed. The term “empty sella” describes a missing pituitary gland in the sella turcica. Up to now, it is not known if routine endocrine assessment is necessary in patients with primary empty sella syndrome (PES) without clinical suspicion or history of neuroendocrine disorders.We performed a systematic literature research u...

Objective: Sexual orientation in males and females is considered to be determined in early life and to be virtually unchangeable in the course of adulthood. In contrast some transsexuals report a change in their sexual orientation most overt following sex reassignment procedures. The reason for this phenomenon is unknown.Methods: We asked 106 transsexual (66 MtF and 40 FtM) patients from our endocrine outpatient clinic to complete a questionnaire, retros...

Background: Glucocorticoid (GC) substitution therapy in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is not able to perfectly mimic physiological circadian profiles. Unphysiologically high doses, as well as unphysiological variations in GC concentrations might cause adverSemetabolic, cardiovascular and immunological effects. Previous publications have demonstrated dysregulations in immune cell profiles of patients with primary adrenal ins...

Background: Hypogonadism is frequent in men with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). It has recently been demonstrated that testicular adrenal rest tumors (TART) are a source of 11-oxygenated androgens that might impair testicular function, in addition to their local compressive effects. Data on long-term course of testicular function in men with 21OHD and the role of potential influential factors such as presence of TART and 11-oxyge...

Background: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is associated with ACTH-driven adrenal androgen excess. In women with classic CAH, this regularly causes prenatal virilisation of the external genitalia, commonly corrected by genital surgery during the first years of life. This practice, however, has been questioned and is discussed highly controversial. The aim of this study was to retrospectively assess the perspective of affected patients and...

Background: Patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) require lifelong glucocorticoid replacement therapy, including stress dose adjustment to prevent life-threatening adrenal crises (AC). Previous studies indicate a high incidence of inadequate stress dose adjustment and AC in patients with CAH. The aim of this study was to prospectively assess AC incidence, frequency and details of stress dose adjustment as well as knowledge of the d...

Background: Symptoms of hyperandrogenism are common in patients with Cushing’s disease (CD), but they cannot be sufficiently explained by measured concentrations of circulating androgens. In this study we analyzed the contribution of 11-oxygenated (11o×C19) androgens to hyperandrogenemia in female patients with CD as well as the influence of treatment with steroidogenesis inhibitors osilodrostat and metyrapone on 11o×C19 and classic androgens.<p class="abste...

Background: There have been conflicting reports on fertility, reproduction rates and pregnancy outcomes in women with congenital adrenal hyperplasia (CAH). Identification of potential modifiable influential factors of pregnancy outcomes in these women has been hampered in the past by either small sample sizes or data derived from epidemiological samples.Methods: Retrospective multi-center study including a total number of 72 women with CAH (n=34...